Description
Product Name: Trifluoromethanesulfonic Anhydride Tf2O CAS: 358-23-6 High Purity
CAS: 358-23-6
Packages: 20 Kg
Main use: an intermediate in the pharmaceutical industry for the production of proteins, glycosides, and vitamins; a catalyst for Friedel-Crafts benzylation and cyclohexylation reactions.
Availability : In Stock
What is Trifluoromethanesulfonic Anhydride(Tf2O)?
Trifluoromethanesulfonic anhydride( Tf2O), also known as triflic anhydride, is an electrophilic reagent that is an efficient source of trifluoromethyl. It is commonly used in organic chemistry to convert oxygen-containing compounds to triflates and for the electrophilic activation and subsequent conversion of amides, sulfoxides, and phosphorus oxides.It is a commonly used intermediate in the pharmaceutical industry, and it is widely used in the synthesis of sterols, proteins, antibiotics, anticancer drugs, and nucleosides.
Certificate of Analysis – High Purity ! 99.5 %
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What are applications of Trifluoromethanesulfonic Anhydride(Tf2O) ?
Trifluoromethanesulfonic anhydride (Tf2O) is a powerful electrophilic reagent used in organic synthesis for triflation reactions, activating functional groups, and as a catalyst. Its uses include converting alcohols to triflates, activating amides, sulfoxides, and phosphorus oxides, synthesizing complex molecules like polysaccharides and tetrazoles, and serving as a polymerization initiator. It is also used as a building block for active ingredients in crop protection and to introduce the trifluoromethyl group (𝐶𝐹3) into molecules.
- Triflation: Converts oxygen-containing compounds like alcohols and phenols into the highly reactive triflate esters (OTf).
- Activation and transformation:
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- Activates amides, sulfoxides, and phosphorus oxides, making them susceptible to nucleophilic attack.
- Can be used for the preparation of substituted tetrazoles from secondary amides.
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- Synthesis of complex molecules:
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- Acts as a catalyst for glycosylation reactions to synthesize polysaccharides and other complex carbohydrates.
- Used in the stereoselective synthesis of compounds like mannosazide methyl uronate donors.
- Serves as a reagent in cyclization reactions like the Bischler−Napieralski cyclization.
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- Introduction of functional groups:
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- Introduces the triflyl group (CF3SO2) into various molecules.
- Used for trifluoromethylation and trifluoromethylthiolation.
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- Catalysis:
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- Serves as a Lewis acid catalyst for reactions such as Friedel-Crafts acylations and other cyclizations.
- Can initiate cationic polymerization, particularly for certain monomers like vinyl ethers.
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- Industrial applications:
- Used as a building block for the active ingredients in products like herbicides and other crop protection agents.
- A catalyst in the plastics industry for polymerization and oligomerization
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